| EDHS Senior Year | Player | Major League Team |
|---|---|---|
| 1976 | Dan Petry | Detroit Tigers |
| 1981 | Kevin Blankenship | Atlanta Braves |
| 1982 | Chris Cron | Atlanta Braves |
| 1987 | Bret Boone | Seattle Mariners |
| 1989 | Phil Nevin | Houston Astros |
| 1989 | Matt Luke | New York Yankees |
| 1991 | Brett Tomko | Cincinnati Reds |
|
1997 |
Toronto Blue Jays |
|
| 2012 | PJ Conlon | New York Mets |